![]() Table 2 lists the main compounds isolated from different species of this genus.Įpi-bicyclosesquiphellandrene, 1,8-cineole, menthofuran, β-caryophyllene, limonene, p-menthone, β-pinene, germacrene D, α-pinene, α-humulene, δ-cadinene, caryophyllene oxide, viridiflorol, viridiflorol epoxide II, α-cadinol, β-bisabolenol, α-trans-bergamotene, p-cymene, borneol, sabinene, β-myrcene, terpinyl acetate, eucalyptol Menthol, menthone, isomenthone, menthyl acetate, linalool, linalyl acetate, lippione, pulegone, carvone, piperitenone oxide and cis-piperitone epoxide are the main constituents of essential oils prepared from different mint species. ![]() They are colorless, pale yellow or greenish yellow and alcohols, ketones, esters, ethers and oxides are their main components in Mentha species. With regard to mint compositions, the essential oils represent a major focus. Flavonoids including luteolin and its derivatives apigenin, acacetin, diosmin, salvigenin and thymonin, have also been detected in these plants, accounting for some 10–70 compounds out of the total phenolics, and also flavanols such as catechin, epicatechin and coumarins, including esculetin and scopoletin. Mentha species are rich in polyphenols and, moreover, contain caffeic acid and its derivatives caftaric acid, cinnamic acid, ferulic acid, and oleanolic acid. Among the plants with global economic and culinary importance, mint is used worldwide for perfuming sweet and savoury dishes and flavouring tea, in addition to its pharmacological importance. Moreover, some of the aforementioned plant-derived compounds have pleasant taste and odor and can be used in kitchen as flavorings, spices and food. Anticancer drugs, antibiotics, anti-inflammatory drugs, immunomodulators are among the most important drugs having herbal origin. In addition, due to contraindications in the usage of chemical drugs, there is a growing interest in the utilization of the plant-derived medicinal products, since compared to synthetic drugs some of these natural products have lower toxicity and higher efficacy. In many developing countries, plant materials have an important role in primary care or disease treatment. Most synthetic bioactive drugs are structurally similar to the phytochemicals of plants from which they were firstly isolated. Today, more than 30% of all medicinal drugs (and their derivatives and analogs) derive from plants, and natural products will continue to possess considerable impact in human medicine. The use of plants in medicine dates back to 60,000 years ago, before the birth of civilization. Medicinal plants and their derived compounds (phytochemicals) have been considered of pharmacological significance since ancient times. ![]() The current review highlights the antimicrobial role of mint-derived compounds and essential oils with a special emphasis on anticancer activities, clinical data and adverse effects displayed by such versatile plants. Essential oils from mint have also been found to exert antibacterial activities against Bacillus subtilis, Streptococcus aureus, Pseudomonas aeruginosa, and many others. Mint essential oils show a great cytotoxicity potential, by modulating MAPK and PI3k/Akt pathways they also induce apoptosis, suppress invasion and migration potential of cancer cells lines along with cell cycle arrest, upregulation of Bax and p53 genes, modulation of TNF, IL-6, IFN-γ, IL-8, and induction of senescence phenotype. Phytochemicals derived from mint also showed anticancer activity against different types of human cancers such as cervix, lung, breast and many others. Mentha species are widely used in savory dishes, food, beverages, and confectionary products. Among medicinal plants, mint ( Mentha species) exhibits multiple health beneficial properties, such as prevention from cancer development and anti-obesity, antimicrobial, anti-inflammatory, anti-diabetic, and cardioprotective effects, as a result of its antioxidant potential, combined with low toxicity and high efficacy. Medicinal plants and their derived compounds have drawn the attention of researchers due to their considerable impact on human health.
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